Author Correction: Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21

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Debris actually pelts the ISS all the time, and noticeable dents and cracks line the exteriors. But should something fully breach the station, cabin atmosphere will seep into the vacuum of space and alarms will go off. Pressure gauges will confirm to astronauts that the station has, almost certainly, been hit, and the speed of the seepages may indicate how much time the crew has to respond. According to one NASA estimate, a 0.6-centimeter-wide hole leaves 14 hours to plug the leak. A 20-centimeter hole leaves less than a minute.

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Stewart Brand thinks big and long. He thinks on a planetary scale – as suggested by the title of his celebrated Whole Earth Catalog – and on the longest of timeframes, as with his Long Now Foundation, which looks forward to the next 10,000 years of human civilisation. He has had a lifelong fascination with the future, and anything that could get us there faster, from space travel to psychedelic drugs to computing. In fact, he was arguably the bridge between the San Francisco counterculture of the 60s and present-day Silicon Valley: in his commencement speech at Stanford University in 2005, Steve Jobs eulogised the Whole Earth Catalog and Brand’s philosophy, and echoed its farewell mantra: “Stay hungry. Stay foolish.”

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